NMT

Generell information

N-Metyltryptamin (NMT), är en tryptamin som återfinns i många växter som innehåller DMT, exempelvis olika arter av Virola, Acacia och Mimosa.

Det är oklart om NMT har psykoaktiv effekt eller ej, det finns både källor som pekar för och emot. 4-HO-analogen av NMT (metabolit av Baeocystin) är däremot psykoaktiv.

To my knowledge there have been no reports of oral activity of NMT, although its wide availability from botanic sources has encouraged some explorers to assay it. I have had one report that the smoking of 50-100 mg gave visuals that lasted for maybe 15 seconds.
— Alexander Shulgin [1]
The following research was conducted 2000-2001.

Phyllodes and (thin strips of) bark of A. obtusifolia were collected from roadside populations (being careful to do as little permanent damage as possible to the trees.) A total alkaloid content of 0.3% (fresh material) was obtained which GCMS determined consisted mainly of monomethyl-tryptamine (NMT) & dimethyltryptamine at a 2:1 ratio. A small amount of presumed Leptocladine (beta-carboline) was present but no reference sample was available.

NMT was separated from the other alkloids by column and paper chromatography using aqueous methanol(10%)/dichloromethane 1:9 (after considerable trial & effort).

In most attempts NMT would not crystalize easily and was usually seen as a white or yellow oil (darkening with exposure to air).

Crystalized samples were subjected to bio-assay by 3 experienced voluntary subjects, in control set and setting conditions.

Upon vapourization of the pure material, it was found that monomethyl-tryptamine has entheogenic effects, becoming noticeable after 3-5 minutes, attaining full strength for 30-45 seconds, and gradually disappearing over 45-70 minutes. No negative or lingering side effects were noted. It was roughly estimated at 1/3 the potency of DMT. It is possible that at very high doses some MAO inhibition may occur (as is the case with 5meoDMT).

The instigating test subject describes it's subjective effects as differing from DMT in being: "...not so much a visual or auditory entheogen, although there were some visuals, but rather a 'Spatial hallucinogen'...imagine you could 'feel' but not see an Escher world...
— nen888[2]

Kemi

140px-Methyltryptamine.png
2-(1H-indol-3-yl)-N-methylethanamine
N-metyltryptamin, NMT
C11H14N2
87 - 89C
174.245 g/mol
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Externa länkar

  1. Erowid Online Texts : TiHKAL #50 NMT av Alexander Shulgin
  2. DMT Nexus: entheogenic effects of NMT (monomethyl-tryptamine)

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